Perimenopause is a significant life stage for women, marked by hormonal shifts that can influence various bodily systems, including brain function. Many women report changes in cognitive function during this time, often described as ‘brain fog’ or difficulties with memory and focus.
Emerging research on lion’s mane mushroom (Hericium erinaceus) suggests a potential role in supporting brain health, particularly through mechanisms related to neurogenesis. This article explores the current understanding of lion’s mane and its connection to the brain, offering evidence-based insights relevant to women navigating midlife and perimenopause.
Understanding Neurogenesis and Brain Health
Neurogenesis is the process by which new neurons are generated in the brain. While once thought to primarily occur during development, it is now known that neurogenesis continues into adulthood, particularly in areas like the hippocampus, which is crucial for learning and memory. Maintaining healthy neurogenesis is considered important for cognitive function and overall brain resilience.
During perimenopause, fluctuating hormone levels, particularly estrogen, can impact brain circuits and neurotransmitter systems. These changes may contribute to some of the cognitive shifts experienced by women, making the support of intrinsic brain processes like neurogenesis an area of interest.
Lion’s Mane and Neurogenesis: Preclinical Evidence
Lion’s mane mushroom contains bioactive compounds, including erinacines and hericenones, which are thought to contribute to its potential effects on the nervous system [1][2]. Preclinical studies, primarily conducted in animal models, have investigated the mushroom’s influence on neurogenesis.
Research suggests that extracts of Hericium erinaceus may promote the generation of new neurons. For instance, one study found that lion’s mane improved recognition memory and induced neurogenesis in the hippocampus and cerebellum of aging, frail mice [3]. Another preclinical investigation indicated that Hericium erinaceus extract reduced anxiety and depressive behaviors in adult mice by promoting hippocampal neurogenesis [4]. These findings suggest a potential link between lion’s mane, neurogenesis, and aspects of cognitive and emotional well-being in animal models.
Further studies in animal models have also explored the neurogenesis-dependent antidepressant-like activity of Hericium erinaceus [5]. Additionally, specific compounds found in lion’s mane, such as erinacines, have been highlighted for their potential neuroprotective effects in preclinical models, which may be related to their influence on neural growth and development [2]. While promising, it is important to remember that these are preclinical findings and human research is needed to confirm these effects.
Supporting Neurite Outgrowth
Beyond neurogenesis, which is the creation of new neurons, lion’s mane has also been explored for its potential to support neurite outgrowth. Neurites are projections from neurons (dendrites and axons) that are essential for transmitting signals and forming connections within the brain. Healthy neurite outgrowth is fundamental for neural plasticity and efficient brain function.
One study, for example, demonstrated that extracts from Hericium erinaceus promoted the neurite outgrowth of retinal ganglion cells [6]. While this specific study focused on retinal cells, it adds to the broader understanding of how lion’s mane compounds might influence neural structures and connectivity. This support for neural networks could indirectly contribute to maintaining cognitive vitality.
Relevance for Perimenopause and Midlife
For women experiencing perimenopause, maintaining robust brain health is a priority. The shifts in hormones during this period can sometimes lead to perceived changes in cognitive function. While direct human studies on lion’s mane and perimenopausal brain health are limited, the preclinical evidence regarding its potential to support neurogenesis and neurite outgrowth offers an interesting area for further exploration.
Supporting the brain’s natural capacity for renewal and connectivity through processes like neurogenesis could be a valuable strategy during midlife. While animal research provides a foundation, more human-specific studies are needed to understand how these mechanisms translate to cognitive benefits for women in perimenopause.
References
- Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review. Frontiers in nutrition, 2025
- Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models. Frontiers in pharmacology, 2025
- Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients, 2019
- Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. Journal of medicinal food, 2018
- Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression. Chinese medicine, 2021
- Extracts from Cordyceps cicadae and Hericium erinaceus promote the neurite outgrowth of retinal ganglion cells. PloS one, 2026
These statements have not been evaluated by the Food and Drug Administration. This information is not intended to diagnose, treat, cure, or prevent any disease. Content is for informational purposes only and is not medical advice; consult a qualified healthcare provider before starting any supplement. As an Amazon Associate we earn from qualifying purchases.